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Although trace metals such as iron and copper are essential for numerous physiological processes, their accumulation or dysregulation can lead to the generation of ROS, contributing to oxidative damage, lipid peroxidation, and impairment of both enzymatic and non-enzymatic antioxidant defenses [69]

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The increased acetylation of p53 resulting from the expression of miR-34a also supports the regulation of SIRT1 mRNA

A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase