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Mn 2+ can be used as an effective T1 weighted MRI contrast agent because of its five unpaired 3d electrons ( 2 ) nanoparticles (NPs) for dual-mode computed tomography (CT)/magnetic resonance (MR) imaging ( 2 nanomaterials can release Mn 2+ more efficiently under tumor microenvironment conditions, which therefore provided an enhanced signal for MRI imaging and can be used for imaging-guided therapy

It is widely known in the medical community that glutathione is the most valuable bodily antioxidant

In brief, the sections were incubated for 90 min at 25 C in blocking solution (10% horse serum in PBS), and then overnight at 4 C with primary antibodies: mouse anti-glial fibrillary acidic protein (GFAP) antibody (1:500, cat# MABN92, Sigma-Aldrich, USA) or mouse anti-ionized calcium binding adaptor molecule 1 (Iba1) antibody (1:500, cat# MABN92, Sigma-Aldrich, USA)

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