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The indirect tests detect antibody induced by virus replication, IgM for recent infection, IgG for recent or past infection

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10.1128/JVI.75.15.7059-7066.2001 Thomson M, Nascimbeni M, Havert MB, Major M, Gonzales S, Alter H, Feinstone SM, Murthy KK, Rehermann B, Liang TJ: The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity

In addition, we observed a downregulation of phospholipids and purine metabolism, and evidence for DNA damage based on decreased levels of guanine uridine, hypoxanthine, and 2-hydroxyadenine as shown in Fig