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Polycythaemia Vera: Treatment with B12 can mask the diagnosis of this blood disorder, so careful monitoring is necessary if B12 is started before a complete diagnosis

doi: 10.1016/j.amjmed.2005.02.026

Weighing the Pros and Cons Let's summarize the potential benefits and drawbacks: Potential Benefits (Limited Evidence, Often Concurrently with Lifestyle Changes): Possible slight energy increase: Some individuals report increased energy levels, potentially improving exercise adherence

Combining it with another GLP-1 or GIP agonist (semaglutide, tirzepatide) would compound the same receptor load and the same GI and hypoglycemia risks with no efficacy evidence to support it