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Studies have shown that IGF-1 can slow the progression of osteoarthritis, a degenerative joint disease characterized by the breakdown of cartilage

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Furthermore, lithium and valproate reduce transport of myo-inositol into the cells, which leads to reduced PKC activity

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However, the presence of iron in monocultured SH-SY5Y cells inhibited the anti-inflammatory action of SO EO, and only (+)-limonene and rasagiline were effective (Fig