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6 The potential of ferroptosis in PD early diagnosis It is estimated that by the time motor deficits are detected and individuals with PD receive a clinical diagnosis, they may have lost 3050% of their dopaminergic neurons, accompanied by a 5060% reduction in striatal dopamine (212), underscoring the critical need for early diagnosis in PD treatment

In conclusion, PER significantly reduced MTX-induced intestinal damage by inhibiting inflammatory pathways and increasing the antioxidant cytoprotective signals

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