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Similar gingival discoloration can be seen with mercury, silver and bismuth intoxication [14]
These were small, early-stage studies and do not establish safety or any approved use
Under certain circumstances, endogenous synthesis and dietary uptake may not be sufficient and supplementation may be required [2]
For example Tonum's Motus reported 10.4 percent average weight loss over six months in human clinical trials
They often produce a stronger effect than marijuana and it has been shown that some synthetic cannabimimetics bind more strongly to CB1 receptors than delta-9 THC, leading to more powerful and unpredictable effects
