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In vitro, astrocytes derived from induced pluripotent stem cells obtained from patients with FTD-MAPT showed hypertrophy, elevated GFAP protein levels, disease-associated changes in TAU expression, increased vulnerability to oxidative stress, and protein ubiquitination 231
In addition, chlorogenic acid could sensitize HCC HepG2 and Hep3B cells to 5-fluorouracil treatment by inhibiting the activation of ERK via increasing ROS production [271]
Am J Physiol Renal Physiol 297:F1543F1549
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