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10.1002/biot.202200029 27 KuschelewskiJ.SchnellbaecherA.PeringS.WehslingM.ZimmerA

Proposed Mechanisms DSIP appears to work through multiple pathways: it may affect GABA-A receptors, the same inhibitory pathways targeted by common sleep medications

Cancer Res 14 , 67516760 (2008)

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This study demonstrates that mice with constitutive NRF2 activation do not develop spontaneous tumours, but the combined activation of the PI3K pathway and NRF2 promotes the development of lung cancer characterized by an immunosuppressive microenvironment, which can be therapeutically exploited by use of immune checkpoint inhibitors