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Pharmacological PKC, Trk, caspase, autophagy, translation, and necroptosis inhibitors Stocks of PKC inhibitor G6976 (10 mm, Tocris 2253), Trk receptor inhibitor K252a (200 m, Calbiochem #420298), pan-caspase inhibitors Boc-D-fmk (10 mm, Abcam ab142036), zVAD-fmk (20 mm, R&D Systems FMK001), and necroptosis inhibitor necrostatin-1 (NEC-1

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Through this methodology, we confirmed the distinct roles of these in maintaining the homeostasis of the Glu-Gln cycle and the expression of normal behaviors

Incretin-based agents are also not expected to cause clinically significant cytochrome P450 (CYP)-mediated pharmacokinetic interactions, meaning the metabolism of testosterone is unlikely to be directly affected