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In BRAF-mutant melanoma, DTP cells emerging after MAPK inhibitor treatment demonstrate increased intracellular calcium signaling via P2X7-mediated ERK reactivation, which supports survival in the drug-tolerant idling state (Stauffer et al., 2024)

Beyond that, based on previous assumptions, lactate was surprisingly discovered to exhibit inhibitory effects on wild GPR81(-) macrophage cell lines, which included abrogating LPS-induced IL-6 expression depending on concentration

[DOI] [PubMed] [Google Scholar] 168.Zhang Z., Zhao H., Ge D., Wang S., Qi B