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Dosage and duration of LAC and -lipoic acid (ALA) have shown no antidepressant effect on patients with BD, which also had insignificant enhancement of mitochondrial function in patients (62, 64)

Men with OAT have been reported to have elevated prostaglandin levels

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The ubiquitous vitamin B 12 -dependent methionine synthase (MS) enzyme also catalyzes the re-methylation of homocysteine, using the folate derivative, 5-methyltetrahydrofolate, as a methyl donor (see Nutrient interactions)