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Meredith JD, Chapman I, Ulrich K, Sebastian C, Stull F, Gray MJ

2025 Apr;242(4):717-724

Molecular analysis covering mutation hotspots and gene fusions/gene skipping was carried out with either Ion AmpliSeq TM V2 Lung/Colon cancer panel (Thermo) or Archer Fusion Plex Lung Panel (ArcherDX) or by using targeted Idylla BRAF, KRAS and EGFR mutation kits (Biocartis)

Although it is primarily known as a genotoxic biomarker and a potential non-invasive serum indicator for patients with non-small-cell lung cancer and breast cancer 87 , elevated levels hold strong clinical relevance, especially in triple-negative breast cancer (TNBC), where baseline levels are comparatively low 88

Hydroperoxide isomerization generates hydroxy-epoxides and keto-epoxides