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Despite the importance of glutamate and NMDAR for the healthy brain, overactivation of glutamate receptors leads to toxic levels of intracellular calcium, which can result in cell death [133, 134], for which the term excitotoxicity was coined [135]

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Weight regain following Retatrutide discontinuation appears consistent with other obesity medications, with 70-85% of lost weight typically returning within 12-18 months without intensive lifestyle intervention

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