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These findings may suggest that the dietary level of folate is not the only determinant for DNA methylation status and that other confounding factors might modulate the role of folate as a methyl donor

Nephrology , 2 , 17583

However, these findings should be regarded as hypothesis-generating and require validation through targeted in vitro functional assays, transcriptomic analyses, and in vivo studies to establish bioavailability, efficacy, and safety under physiological conditions

N.ArltW.OReillyM

Mucha O, Podkalicka P, Kazird K et al (2021) Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy