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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

IBS or Inflammatory bowel diseases like Crohns or Ulcerative colitis Short bowel syndrome Pancreatic disease like pancreatitis or pancreatic insufficiency, where the pancreas isnt producing enough enzymes to break down your food

Biochim Biophys Acta Rev Cancer 1766:122 Lang CH, Nystrom GJ, Frost RA (1999) Regulation of IGF binding protein-1 in hep G2 cells by cytokines and reactive oxygen species

Interestingly, NNMT expression was elevated in atorvastatin- and pravastatin-treated endothelial cells, which elevated nitric oxide and reactive oxygen species (ROS) (35)