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doi: 10.1111/ajt.14107 56 MengelMLoupyAHaasMRoufosseCNaesensMAkalinEet al
10.1016/j.neuroscience.2011.11.029 41 ChangY
Frequency: Treatment protocols can vary, but injections are often administered several times per week initially, with maintenance doses as needed
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Primary resistance is thought to stem from pre-existing heterogeneity within a tumor: rare subpopulations or stress-tolerant cells that harbor survival advantages can survive first-line therapy
