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The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]

281, 1036510373 10.1074/jbc.M513094200 [DOI] [PubMed] [Google Scholar] 25.Otreba M., Rok J., Buszman E

52,53 Additional examples of bioactive factors used in pre-clinical and clinical trials are included in Table 1, all of which suggest that tailored growth factor delivery may improve cartilage repair in aged patients

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