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In one study, the CD44 rs1467558 polymorphism was reported to be significantly associated with an ALT rise in independent cohorts of patients given a therapeutic dose of 4 g/day of paracetamol over 7 days [42]

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PMID 15731165

A possible explanation is that Ly6C Hi monocytes, known as inflammatory monocytes, rapidly migrate to inflamed sites and generally express low baseline levels of CD36 (thus relying heavily on RIPostC -induced upregulation), whereas Ly6C Low monocytes inherently possess higher CD36 expression, making the effect of RIPostC less pronounced