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Vitamin B12 is reduced to cobalamin regardless of form (cyan-, methyl-, adenosyl-, hydroxo-) then re-assembled as methylcoblamin by MS for use in the cytosol, or adenosylcobalamin by MM for use in the mitochondria

The label reflects two properties: it neutralises reactive oxygen species (free radicals) directly, and it also recycles other antioxidants including vitamins C and E back to their active reduced forms

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684 The small molecule pyrrolidine dithiocarbamate 646 (Table 7) is a copper chelator that was shown to affect NF-B, JNK, and activating protein-1 (AP-1) signaling in various cancer cell lines, providing the basis for new therapeutic strategies

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