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Grant et al

This suggested that the mechanisms underlying chronic nociceptive processing differ as a function of sex and gonadal hormone status [346]

Acute and subacute inhalation toxicity of Turkish marihuana, cannabichromene, and cannabidiol in rats

Among chronic DILI, persistent DILI is defined by the International Expert Committee in 2011 as abnormalities in liver markers persisting for more than 3 months in the hepatocellular injury type and more than 6 months in the cholestatic injury type after discontinuation of the causative drug, whereas chronic DILI is defined as abnormalities in liver markers persisting for more than 12 months regardless of the phenotype of DILI. 24 Chronic DILI may cause drug-induced AIH (DI-AIH), nonalcoholic steatohepatitis-like conditions, vanishing bile duct syndrome, nodular regenerative hyperplasia, peliosis hepatis, and liver cirrhosis (Table 1)

68 , 82 It is unlikely, however, that rising blood levels of the cytokines TNF, IL-6, and IL-8 initiate the JHR because the chill and temperature rise start as early as 30 minutes to 1 hour after antibiotic treatment, 28 , 68 , 73 when blood levels of these cytokines, already elevated before antibiotic treatment, stay about the same for 30 minutes to 1 hour after treatment