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In vitro, a novel recombinant expression vector, pcDNA3.1(-)-VEGF, was produced and transfected into the fibroblast cells

After reaching 65/70 years of age, the circadian rhythm of melatonin secretion almost completely disappears. MELATONIN IN SLEEP DISORDERS Melatonin as a hormone regulating the day-night circadian rhythm and seasonal biorhythm also participates in the process of mood, sleep, and its quality

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Furthermore, GCLC-KO mouse will serve as a useful tool to investigate the molecular mechanisms underlying neurodegeneration and in the development of new treatment strategies to address neurodegenerative diseases.

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