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CAT polymorphism (330CC genotype) showed a significant association with thrombocytopenia, renal manifestations, as well as production of anti-snRNP and anti-Scl-70 antibodies in SLE patients [8]

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10.1111/liv.15600 86 MaccioniL.GaoB.LeclercqS.PirlotB.HorsmansY.DE TimaryP.et al (2020)

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The earlier ADCs, such as BR96-DOX and Mylotarg@, did not have a sufficient therapeutic index and had been withdrawn from the market, which was attributed to the poor stability of linkers [4,40]