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Despite the acknowledged significance of vitamin B12 for the nervous system and the risks of its deficiency, there remains an insufficiency of research on the relationship between vitamin B12 and sleep disorders, including the specific blood level thresholds that could trigger such disorders

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In 2013, a study published in the Journal of Endocrinology and Metabolism evaluated six studies of fragment 176-191 to assess the rate and significance of negative effects associated with the peptide