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The published preclinical work (Neelakantan et al., referenced via PMC5826726) reported clean safety at 20 mg/kg subcutaneous in mice over 11 days
Interestingly, even in studies where beta-3 receptors were absent, some metabolic effects persisted with acute dosing, suggesting secondary mechanisms may exist
Neuroprotective effects have been observed in certain models of neurological damage
Similarly, AVP-825 (Onzetra Xsail) is a sumatriptan nasal powder approved in 2016 for the acute treatment of migraine in adults
More specifically, I want to share what Ive learned while looking after General during his last days
