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Fukuzawa, Y

have created mouse models like the aging FAD4T, AD-specific APP/PS1, and mature microglial Dox-BV2, showing that H3K18la enhances NFB signaling by upregulating the expression of Rela (p65) and NFB1 (p50) [76]

Temporally, CRC exhibits distinct metabolic evolution during progression from primary to metastatic disease [107]

CB1 knockout mice also showed a higher sensitivity to exhibit depressive-like responses in the chronic unpredictable mild stress procedure suggesting an increased susceptibility to develop an anhedonic state (Martin et al., 2002)

[ 7 ] Despite these advances, macromolecular drugs, particularly when administered orally, face significant challenges in bioavailability