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*Correspondence: Lianzhong Ai, [email protected]

Presence of antioxidative agent, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro- in newly isolated Streptomyces mangrovisoli sp

Studies have shown that hesperidin can reduce reactive oxygen species (ROS) levels by 60% and increase the activity of antioxidant enzymes like glutathione peroxidase (GPx) in cancer cells, leading to decreased oxidative damage and cell growth

For gene-set enrichment analysis, gene sets from the Molecular Signatures Database (v.2023.2) were used

In contrast, agents directly targeting the ECM, such as PEGylated hyaluronidase (PEGPH20), have shown limited efficacy as monotherapies in patients with hyaluronan-high metastatic pancreatic cancer, prompting ongoing efforts to optimize combination strategies that address multiple barriers simultaneously [211]