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On the other hand, chronic sterile inflammation, characterized by aberrant activation of the immune system, enhanced expression of pro-inflammatory cytokines, such as TNF-, IL-1, IL-6 and IL-18, and activation of immune complexes, such as the NLRP3 inflammasome, is now being recognized as a key driver of disease progression in heart failure [156, 157]

Laryngoscope (2004) 114:8559

Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat

However, despite these upward and downward trends in the rates, the observed changes were not statistically significant (Figure 4)

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