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If youre correcting a deficiency, you might start with weekly injections and shift to monthly maintenance

Mechanosensitive Piezo receptors (particularly the Piezo1 subtype) are found in the injury perception of the peripheral trigeminal nerve, and high-dose injections of Yoda1 can extend the meningeal arteries innervated by the trigeminal afferent nerve, leading to the development of migraines (Dolgorukova et al., 2021