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Mitochondrial dysfunction, a key feature of AD, further exacerbates ROS production, impairs ATP generation, disrupts calcium homeostasis, and ultimately induces neuronal apoptosis (Bhatt et al., 2021)
In cardiomyocytes, GATA4 represses autophagy by upregulating Bcl2 , which binds and inhibits BECN1, thereby blocking autophagosome initiation
K., & Maiti, T
[DOI] [PubMed] [Google Scholar] 17.Mynott TL, Ladhams A, Scarmato P, Engwerda CR
This secretory phenotype is known as the senescence-associated secretory phenotype (SASP)
