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For mood, epidemiological data links low dietary magnesium intake with higher rates of depression, and a randomized trial found magnesium chloride supplementation as effective as imipramine (a tricyclic antidepressant) in reducing depression scores in hypomagnesemic elderly patients [12]

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[DOI] [PubMed] [Google Scholar] 29.Poortmans J.R., Auquier H., Renaut V., Durussel A., Saugy M., Brisson G.R

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Specifically, l-carnitine treatment can reduce synovitis by inhibiting AMPK-ACC-CPT1 pathway activation and showed an increase in fatty acid -oxidation, a lower lipid accumulation, and a noticeable improvement in mitochondrial function