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Additionally, it was demonstrated that DUOX1 expression was lower in HCC than in healthy reference tissues, and this lower expression was associated with CpG island methylation in the promoter of the gene

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Of note, through histopathological and immunofluorescence analyses of immune cell subsets, we confirmed that lowering oxalate via AGXT overexpression or pharmacological inhibition of LDHA and GO reduces steatohepatitis aligned with the decrease in distinct subsets of recruited monocyte-derived macrophages (CCR2 + and TREM2 + macrophages) that are known to infiltrate the liver in MASH and form crown-like structures surrounding hepatocytes with large lipid droplets 49

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There is evidence that the level of serotonin in the brain exhibits circadian rhythmicity [64]

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Hypoxia-inducible factor 1 in autoimmune diseases

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