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Argaev-Frenkel L, Rosenzweig T

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however, these effects were proportionally larger, with large effect sizes on most measures

If this process is inhibited, for example by thiamine deficiency, lactate will build up

Therefore, HIF-1 likely exerts a suppressive effect on ferroptosis in affected cells by upregulating antioxidant systems, exerting a protective role similar to its anti-apoptotic effects in osteoblasts
