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Solid-phase refolding of cyclodextrin glycosyltransferase adsorbed on cation-exchange resin

USA 111 , 1555015555 (2014)

At the same time, liposomal nanoparticles LNP-CDN loaded with cyclic dinucleotides (CDN) can not only protect CDN from enzymatic degradation in malignant pleural effusion (MPE) but also specifically target macrophages and DCs, in addition, LNP-CDN alone or in combination with anti-PD-L1 antibody can not only lead to significant up-regulation of M1-related genes in TAMs, promote NK cells maturation and enhance the cytotoxic activity of NK cells, but also significantly increase the number of CD8 + T cells and reduce the volume of MPE, inhibit tumor growth, and ultimately significantly prolonging the survival of MPE tumor-bearing mouse (222)

doi: 10.1093/mutage/7.1.25

J Carcinog