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These studies showed the importance of the mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinases-protein kinase B (PI3K-AKT) signaling pathways, whose activation is considered the primary oncogenic event in PTC carcinogenesis, as well as in other pathological states [4, 5]

Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid