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Cognitive interviewing methodology in the development of a pediatric item bank: a patient reported outcomes measurement information system (PROMIS) study

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The inability to adapt to the different cellular and environmental needs/stressors results in metabolic inflexibility, which ultimately leads to disease states like insulin resistance, lipid accumulation, and an inability to maintain homeostatic balance [2426] (Figure 6)

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196 Similarly, upregulated PRMT3-mediated H3K18la drives PD-L1-mediated immune escape by activating PDHK1-regulated glycolysis in HCC cells