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Collectively, these findings suggest that in individuals with a genetic predisposition, the pathophysiology of migraine is characterized by repeated activation and sensitization of trigeminal nerves by meningeal inflammation, influenced by significant brain activity and resulting in structural and functional brain changes (36)

Garca-Alonso et al

doi: 10.1016/S0020-7292(03)00079-1

Increased muscle mass
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