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Calculation: Animal Dose (mg/kg) x (Mouse Km / Human Km) Math: 15 x (3 / 37) = 1.21 mg/kg

10.1074/jbc.R111.283432 J
Following an apoptotic stimulus, Bax is activated and translocates to the mitochondria, where it undergoes a conformational change and inserts into the OMM

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Le VQ, Zhao B, Ramesh S, Toohey C, DeCosta A, Mintseris J, Liu X, Gygi S, and Springer TA (2023)

Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-like Lesions in Mice via NRF2 Activation
