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Figure 5 Cysteine Histidine-Dependent Amidohydrolases/Peptidases (CHAP) The CHAP domain is around 120 amino acids long (IPR007921) with the unique feature to be potentially involved in two different CW cleavage activities (Bateman and Rawlings, 2003)

L-carnitine is a supplemented amino acid derivative

8 However, many patients previously diagnosed with EDS-HT/JHS will not meet the stricter set of criteria for hEDS under the new nosology

An apoprotein (APO) is the protein moiety of a conjugated protein, or a protein complex (this term is synonym for apolipoprotein, which was originally coined by John Oncley in 1963) [10,11]