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Finally, utilizing artificial redox mediators or label-based sensing architectures allows the system to operate at significantly lower or negative potentials

These results suggest that aged cells have alterations in the vesicular clearance mechanisms driven by Rab7 and Arl8b GTPases, which could be caused by the bioenergetic deficits of intracellular free GTP in old age

Cell nuclei were stained with DAPI (dilution 1:5000, Invitrogen)

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