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Compared to healthy age-matched individuals whose samples were taken before the pandemic started in 2019, patients hospitalized with COVID-19 had significantly increased levels of oxidative stress and oxidant damage, and markedly reduced levels of glutathione

Diagnostic Utility of GSTs in Kidney Disease The GST protein family is divided into three major subclasses , , and , while the and forms exist in human kidney with relatively high amounts in renal tubules

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This activates NF-B to trigger neuroinflammation, ultimately exacerbating SNpc dopaminergic neuron apoptosis in PD (162)

However, the imbalance of metal ions, whether deficiency or excess, can lead to metabolic disorders, cell and tissue damage, weakened immunity and neurological dysfunction (Tian et al., 2024)