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While iron-based Fenton reactions produce hydroxyl radicals (OH), their effectiveness requires an acidic environment, prompting exploration of metals like Mn and Cu that offer superior catalytic performance [76]

The extracellular region of RAGE comprises a variable (V) immunoglobulin (Ig) domain followed by two constant Ig domains (C1 and C2), which are connected by a flexible linker [222]

These complexes can deposit in tissues, initiating an inflammatory response and resulting in damage to multiple organs (46)

Widner, and C

Importantly, some fungal-specific enzymes offer high target selectivity with minimal risk to the host