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10.1007/s10620-019-05777-2 21

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One explanation for this phenomenon may be attributable to the solubility of VIC, which must be transported across the bloodbrain barrier in an active mode to reach the CNS

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However, during inflammatory reactions, exposure of macrophages to interferon (IFN) and TNF results in the activation of the inducible isoenzyme of NOS (iNOS), which increases up to 10 times the levels of nitric oxide
