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In addition, MOTS-c was also found to have the same effects in an acute lung injury model, reducing pulmonary edema and inhibiting lung tissue neutrophil infiltration through downregulation of cytokine-induced neutrophil chemotactic factor-1 (CINC-1) and intercellular adhesion molecule-1 (ICAM-1) expression in lung tissue [45]

Topical probiotic formulations, in particular, are emerging as promising strategies in wound care, with their effectiveness largely attributed to the secretion of antimicrobial metabolites, including hydrogen peroxide (306) and bacteriocin (307), which inhibit the growth of pathogens and reduce the risk of infection

Preclinical Research Summary Preclinical investigations involving the individual peptides included in this formulation have provided valuable insights into their biological activity in experimental models

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In some animals, the therapy was administered once at a later time after additional colon obstruction (IC + OB rats)