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In order to rescue the expression of chimeras M1, M3, M4 and M7, and increase the expression of M2, we tested the effectiveness of the chemical chaperone 4-phenyl butyric acid (4-PBA) 37 , at 5 mM for 24 h in comparison with MRP1 wild type (WT) expression in the same conditions

Beyond the traditional adverse reactions and delivery obstacles, drug resistance, as a more profound limiting mechanism, is also becoming increasingly prominent in ADC therapy

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The metabolic profiling revealed that AOD9604 undergoes rapid proteolytic degradation in serum, generating a series of predictable fragment peptides

It works by protecting mitochondria, the energy powerhouses of your cells, from oxidative stress