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Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

KODL TAI NAUDINGA

In particular, we previously showcased that caffeine, at doses borderline for eliciting arousal [10, 11] and locomotor activity [7, 12], can functionally antagonize alcohol reinforcement by demonstrating that it could prevent the acquisition of alcohol-elicited conditioned place preference and aversion [13], pointing to the dopamine (DA)-dependent underlying associative learning process [14] as the possible mechanism targeted by caffeine to gain this behavioral outcome

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In the ADVANCE study including 11,140 patients with type 2 diabetes randomly assigned to either standard glucose control or intensive glucose control, the relative risk reduction (95% CI) for new or worsening neuropathy for intensive vs