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The Influence of the Gut Microbiome on the Neuronal Excitability of AH Neurons In addition to being regulated by enteroendocrine peptides and 5-HT, immune/inflammatory mechanisms, and neurotransmitters, the excitability of AH neurons can also be influenced by the gut microbiome and microbial mediators (FIGURE 5)

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The front CtpA undergoes a series of conformational changes, in particular the PDZ domain is far away from the position in the back CtpA, when the two protease structures are aligned by their respective core domains

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