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The BCAAs are transaminated in muscle mitochondria by branched-chain aminotransferase (BCAT), and branched-chain -keto acids (BCKAs, especially -keto acid from leucine) inhibit branched-chain -keto acid dehydrogenase kinase, resulting in elevation of the active state of the rate limiting enzyme branched-chain -keto acid dehydrogenase complex (BCKDH)

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