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In: StatPearls

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An individuals TMAO productivity was determined by calculating the AUC of the OCCT curve (OCCT TMAO AUC ) or by using the OCCT TMAO MAX level

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Increased ALOX5 expression elevated leukotriene B4 levels, promoted M1 macrophage polarization, and worsened cardiac injury, whereas ALOX5 knockout or pharmacological inhibition with zileuton reduced inflammation, preserved cardiac function, and improved survival (Xie et al., 2021)