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Vitamin C is a moderately weak acid (pKa= 4.25), only slightly stronger than vinegar (pKa=4,75)
Additionally, new therapeutics being developed are presented and discussed, as they can improve the current treatment options
Despite the currently available data, the possibility that melatonin is produced in other subcellular organelles in addition to mitochondria cannot be precluded (56) and there is the possibility some cells have lost this capacity
The preplanned/predeclared first exploratory efficacy endpoint was the change in VAS (principal efficacy variable) from baseline to V4/EoT
